THE UNIVERSITY OF CHICAGO
Raman Lab Papers
Subspecies phylogeny in the human gut revealed by co-evolutionary constraints across the bacterial kingdom
With the advent of sequencing, biological systems like bacteria can be described in a myriad of ways, including by their entire genome sequence. But, with this capacity...
Conserved principles of spatial biology define tumor heterogeneity and response to immunotherapy
Emergent phenomena are everywhere in biology—from macro-ecosystems like birds flocking and ants foraging down to the scale of ecosystems of amino acids that comprise a...
Statistical design of a synthetic microbiome that clears a multi-drug resistant gut pathogen
Given a set of parts and no pre-determined instruction manual on how to put these parts together, how can we create a system that works? The concept of microbiome...
Defining hierarchical protein interaction networks from spectral analysis of bacterial proteomes
If one were to buy a furniture set and accidentally lose the instruction manual, could we put the furniture back together? This is the question facing biologists all...
A sparse covarying unit that describes healthy and impaired human gut microbiota development
The human gut microbiome is comprised of many species that all interact in strange ways so that we can be healthy and veer off disease. Given its importance, what is a...
Origins of Allostery and Evolvability in Proteins: A Case Study
Nature creates wonderfully complex micromachines known as proteins. While much effort has gone into understanding how these machines fold into compact structures and...